Date of Completion
2016
Document Type
Honors College Thesis
Department
Department of Psychiatry
Thesis Type
Honors College, College of Arts and Science Honors
First Advisor
Julie Dumas, PhD.
Second Advisor
Eugene Delay, PhD
Third Advisor
John Green, PhD
Keywords
insulin, estrogen, menopause, fMRI
Abstract
Insulin has an important role in cognition, in addition to its well-known functions in peripheral glucose metabolism. Impaired insulin signaling has been linked to the cognitive decline seen in type 2 diabetes and Alzheimer’s Disease (de la Monte & Wands, 2008). This study examined the effect of insulin on fMRI brain activation during working memory and episodic memory tasks in six postmenopausal women. The goal of this study was to understand how the hormonal change after menopause modifies insulin signaling and how this subsequently impacts fMRI brain activation and cognition. Subjects were tested under conditions of high peripheral insulin levels compared to low levels on two separate study days; these levels were manipulated by ingestion of glucose or water on either study day. We found that high peripheral insulin levels resulted in increased brain activation in both the working memory and episodic memory tasks. Results from this study suggest that insulin functionally changes cognitive processes in the brain in postmenopausal women, however further research is needed in order to understand these changes and their underlying mechanisms.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Recommended Citation
Searles, Sienna Marie, "Effects of Insulin on Brain Functioning in Postmenopausal Women" (2016). UVM Patrick Leahy Honors College Senior Theses. 117.
https://scholarworks.uvm.edu/hcoltheses/117