Date of Completion
2023
Document Type
Honors College Thesis
Department
Department of Neurological Sciences
Thesis Type
Honors College
First Advisor
Gary Mawe
Second Advisor
Janet Murray
Third Advisor
Brigitte Lavoie
Keywords
Serotonin, 5-HT4 Receptor, Intestinal Motility, Constipation
Abstract
Functional gastrointestinal disorders are very common, with a frequent symptom of these conditions being constipation. One of the most effective treatments for constipation involves 5-HT4 receptor agonists, but it is unclear as to whether they act on receptors in the mucosa or muscularis. Motility assays were performed with test compounds that activate the 5-HT4 receptor on transgenic mouse strains in which this receptor is tissue-specifically downregulated. The agonists were found to have inconsistent results on the different mouse strains, which may be a result of ineffective knockdown of the receptors.
Creative Commons License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.
Recommended Citation
Gagne, Jessica E., "Localization of the Receptors that Mediate the Prokinetic Effects of 5-HT4 Agonists on Propulsive Motility" (2023). UVM Patrick Leahy Honors College Senior Theses. 636.
https://scholarworks.uvm.edu/hcoltheses/636