Date of Completion


Document Type

Honors College Thesis


Department of Neurological Sciences

Thesis Type

Honors College

First Advisor

Gary Mawe

Second Advisor

Janet Murray

Third Advisor

Brigitte Lavoie


Serotonin, 5-HT4 Receptor, Intestinal Motility, Constipation


Functional gastrointestinal disorders are very common, with a frequent symptom of these conditions being constipation. One of the most effective treatments for constipation involves 5-HT4 receptor agonists, but it is unclear as to whether they act on receptors in the mucosa or muscularis. Motility assays were performed with test compounds that activate the 5-HT4 receptor on transgenic mouse strains in which this receptor is tissue-specifically downregulated. The agonists were found to have inconsistent results on the different mouse strains, which may be a result of ineffective knockdown of the receptors.

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 License.