Effects of Early Life Seizures on Behavior in C57bl/6J and DBA/2J Mice
Conference Year
January 2019
Abstract
Childhood epilepsy has been shown to increase risk of cognitive impairments later in life. To better understand these difficulties, the early life seizure (ELS) model is used on both C57bl/6J and DBA/2J mice. The mice go through a five-day seizure protocol with four seizures a day, starting at post-natal day eleven (p11). Between p30 and p35, the behavior battery starts, which includes; fear acquisition and extinction, social interaction and novelty, and open field. Strain differences in seizure susceptibility have been found and phenotypic differences in behavior were assessed. Nissl staining for cortical lamination and fluorescent staining astrocytes is used in addition to the behavioral data.
Primary Faculty Mentor Name
John Matthew Mahoney
Status
Undergraduate
Student College
College of Arts and Sciences
Program/Major
Neuroscience
Primary Research Category
Biological Sciences
Effects of Early Life Seizures on Behavior in C57bl/6J and DBA/2J Mice
Childhood epilepsy has been shown to increase risk of cognitive impairments later in life. To better understand these difficulties, the early life seizure (ELS) model is used on both C57bl/6J and DBA/2J mice. The mice go through a five-day seizure protocol with four seizures a day, starting at post-natal day eleven (p11). Between p30 and p35, the behavior battery starts, which includes; fear acquisition and extinction, social interaction and novelty, and open field. Strain differences in seizure susceptibility have been found and phenotypic differences in behavior were assessed. Nissl staining for cortical lamination and fluorescent staining astrocytes is used in addition to the behavioral data.