Presenter's Name(s)

Isabel StewartFollow

Primary Faculty Mentor Name

Frances Carr

Status

Undergraduate

Student College

College of Agriculture and Life Sciences

Program/Major

Molecular Genetics

Primary Research Category

Arts & Humanities

Presentation Title

Establishing the role of Thyroid and Estrogen receptors in regulating the oncogene RUNX2 in thyroid cancer

Time

3:00 PM

Location

Silver Maple Ballroom - Biological Sciences

Abstract

Thyroid cancer will be the 3rd most common cancer among females by 2019[i] and is currently 3 times more prevalent among females than males[ii]. In fact, a study published in 2017 suggests that the incidence of thyroid cancer has increased 3.6% per year between 1974 and 2013[iii]. Because of the dramatic increase in incidence, it’s imperative to better understand the mechanisms by which oncogenesis is increasing. The purpose of this study is to better understand the role of thyroid and estrogen hormone receptors (ERs) as well as the role of RUNX2 in thyroid tumorigenesis by looking at the relationship between them and how they are different between normal and malignant cell lines. Moreover, whether it is the ratio between tumor promoter ERα and tumor repressor TRβ that leads to tumorigenesis. The second purpose of this study is to better understand the influence that estrogen has on thyroid tumorigenesis.

[i] Aschebrook-Kilfoy, B., et al., The Acceleration in Papillary Thyroid Cancer Incidence Rates is Similar Among Racial and Ethnic Groups in the United States. Annals of Surgical Oncology, 2013. 20(8): p. 2746-2753.

[ii] Manole, D., et al., Estrogen promotes growth of human thyroid tumor cells by different molecular mechanisms. The Journal of clinical endocrinology and metabolism, 2001. 86(3): p. 1072-1077.

[iii] Lim, H., et al., Trends in Thyroid Cancer Incidence and Mortality in the United States, 1974-2013. JAMA, 2017. 317(13): p. 1338-1348.

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Establishing the role of Thyroid and Estrogen receptors in regulating the oncogene RUNX2 in thyroid cancer

Thyroid cancer will be the 3rd most common cancer among females by 2019[i] and is currently 3 times more prevalent among females than males[ii]. In fact, a study published in 2017 suggests that the incidence of thyroid cancer has increased 3.6% per year between 1974 and 2013[iii]. Because of the dramatic increase in incidence, it’s imperative to better understand the mechanisms by which oncogenesis is increasing. The purpose of this study is to better understand the role of thyroid and estrogen hormone receptors (ERs) as well as the role of RUNX2 in thyroid tumorigenesis by looking at the relationship between them and how they are different between normal and malignant cell lines. Moreover, whether it is the ratio between tumor promoter ERα and tumor repressor TRβ that leads to tumorigenesis. The second purpose of this study is to better understand the influence that estrogen has on thyroid tumorigenesis.

[i] Aschebrook-Kilfoy, B., et al., The Acceleration in Papillary Thyroid Cancer Incidence Rates is Similar Among Racial and Ethnic Groups in the United States. Annals of Surgical Oncology, 2013. 20(8): p. 2746-2753.

[ii] Manole, D., et al., Estrogen promotes growth of human thyroid tumor cells by different molecular mechanisms. The Journal of clinical endocrinology and metabolism, 2001. 86(3): p. 1072-1077.

[iii] Lim, H., et al., Trends in Thyroid Cancer Incidence and Mortality in the United States, 1974-2013. JAMA, 2017. 317(13): p. 1338-1348.