Presentation Title
Supramolecular Shape-Control with Chirality-Assisted Synthesis
Abstract
The organic world depends on proteins, which are complex polymers that have shape-determined functionality. Despite understanding the properties that dictate protein polymerization, predicting protein structure de novo remains a frontier in protein chemistry. This presentation summarizes recent advancement in chirality-assisted synthesis (CAS), a technique that accomplishes sequence-defined polymers via manipulating the chirality of the monomers. The following work describes both linear and non-linear polymers that exhibit directionality, akin to that observed in biomolecules. This has served as framework for recent work in the Schneebeli Group aimed to identify a novel, synthetic methodology that generates shape-controlled polymers.
Primary Faculty Mentor Name
Severin Schneebeli
Graduate Student Mentors
Jessica Bocanegra
Status
Undergraduate
Student College
College of Arts and Sciences
Program/Major
Biochemistry
Primary Research Category
Engineering & Physical Sciences
Supramolecular Shape-Control with Chirality-Assisted Synthesis
The organic world depends on proteins, which are complex polymers that have shape-determined functionality. Despite understanding the properties that dictate protein polymerization, predicting protein structure de novo remains a frontier in protein chemistry. This presentation summarizes recent advancement in chirality-assisted synthesis (CAS), a technique that accomplishes sequence-defined polymers via manipulating the chirality of the monomers. The following work describes both linear and non-linear polymers that exhibit directionality, akin to that observed in biomolecules. This has served as framework for recent work in the Schneebeli Group aimed to identify a novel, synthetic methodology that generates shape-controlled polymers.