Neurophysiological and Behavioral Correlates of Post-Concussion Syndrome: A scoping review and validation of methods
Conference Year
January 2021
Abstract
INTRODUCTION: Mild traumatic brain injury (mTBI) is caused by an impact or jolt to the head which results in a physiological disruption to the brain. While typically symptoms such as headache, nausea, dizziness and fatigue subside within the first 10 days, a subset of patients fail to recover within this time span and develop prolonged neurophysiological and behavioral symptoms characteristic of post-concussion syndrome (PCS). There is an extensive body of research investigating the various cognitive, physical, emotional, and neurological deficits correlated with PCS. Previous research is yet to depict a complete understanding of the prolonged structural and functional changes that occur within the brain as a result of mTBI. While there are numerous studies assessing the behavioral and neurophysiological correlates of PCS, with my knowledge, there remains a need for these papers to be gathered and reviewed. Therefore, the objective of this paper was to conduct a scoping review of the literature reporting on the neurophysiological and behavioral correlates of patients in the sub-acute and chronic phase (i.e., > 10 days post-injury) following mTBI. METHODS: MEDLINE/Ovid, Web of Science, CINAHL, Cochrane, and PsycINFO were searched for studies from 1994 to November 2020 that investigated the neurophysiological and behavioral correlates in the sub-acute and chronic phase following mTBI. Exclusion criteria included: treatment or intervention studies, moderate or severe traumatic brain injury, Post Traumatic Stress Disorder (PTSD)/Psychological symptoms as primary diagnosis, < 19 years old, animals, cells/tissue/histology, currently enrolled in therapy (pharmacological or non-pharmacological treatment), and deep brain stimulation. Studies also had to fit within the following inclusion criteria: electronically available, humans, 1994 onward, full text, English, sub-acute, chronic, post concussion syndrome. 336 citations were identified, of which 24 studies were eligible for inclusion in the primary analysis. RESULTS: We are currently analyzing our results and anticipate to have results by the end of the 1st week of April, 2021.
Primary Faculty Mentor Name
Sambit Mohapatra
Status
Undergraduate
Student College
College of Arts and Sciences
Program/Major
Neuroscience
Primary Research Category
Health Sciences
Neurophysiological and Behavioral Correlates of Post-Concussion Syndrome: A scoping review and validation of methods
INTRODUCTION: Mild traumatic brain injury (mTBI) is caused by an impact or jolt to the head which results in a physiological disruption to the brain. While typically symptoms such as headache, nausea, dizziness and fatigue subside within the first 10 days, a subset of patients fail to recover within this time span and develop prolonged neurophysiological and behavioral symptoms characteristic of post-concussion syndrome (PCS). There is an extensive body of research investigating the various cognitive, physical, emotional, and neurological deficits correlated with PCS. Previous research is yet to depict a complete understanding of the prolonged structural and functional changes that occur within the brain as a result of mTBI. While there are numerous studies assessing the behavioral and neurophysiological correlates of PCS, with my knowledge, there remains a need for these papers to be gathered and reviewed. Therefore, the objective of this paper was to conduct a scoping review of the literature reporting on the neurophysiological and behavioral correlates of patients in the sub-acute and chronic phase (i.e., > 10 days post-injury) following mTBI. METHODS: MEDLINE/Ovid, Web of Science, CINAHL, Cochrane, and PsycINFO were searched for studies from 1994 to November 2020 that investigated the neurophysiological and behavioral correlates in the sub-acute and chronic phase following mTBI. Exclusion criteria included: treatment or intervention studies, moderate or severe traumatic brain injury, Post Traumatic Stress Disorder (PTSD)/Psychological symptoms as primary diagnosis, < 19 years old, animals, cells/tissue/histology, currently enrolled in therapy (pharmacological or non-pharmacological treatment), and deep brain stimulation. Studies also had to fit within the following inclusion criteria: electronically available, humans, 1994 onward, full text, English, sub-acute, chronic, post concussion syndrome. 336 citations were identified, of which 24 studies were eligible for inclusion in the primary analysis. RESULTS: We are currently analyzing our results and anticipate to have results by the end of the 1st week of April, 2021.