Validation of a modified rat model for erectile function evaluation
Conference Year
January 2022
Abstract
The in vivo model for evaluation of erectile function in rats and mice has been widely used to investigate pathophysiology and treatment modalities of erectile function. The model is technically challenging which limits its broad availability. We have recently introduced a simplified surgical technique for dissection of corporal bodies and developed a new method to achieve stable contact between the cavernous nerve and the stimulating electrode without the need to manipulate the nerve between stimulations using 2-component silicone glue. The goal of this study was to validate this new technique and describe in detail the technical aspects of the procedure so that researchers with basic microsurgery skills can adopt it.
Primary Faculty Mentor Name
Peter Zvara
Faculty/Staff Collaborators
Sabrina Toft Hansen, Lars Lund
Status
Medical Students
Student College
Larner College of Medicine
Program/Major
Health Sciences
Primary Research Category
Health Sciences
Validation of a modified rat model for erectile function evaluation
The in vivo model for evaluation of erectile function in rats and mice has been widely used to investigate pathophysiology and treatment modalities of erectile function. The model is technically challenging which limits its broad availability. We have recently introduced a simplified surgical technique for dissection of corporal bodies and developed a new method to achieve stable contact between the cavernous nerve and the stimulating electrode without the need to manipulate the nerve between stimulations using 2-component silicone glue. The goal of this study was to validate this new technique and describe in detail the technical aspects of the procedure so that researchers with basic microsurgery skills can adopt it.