The Impact of ONC-201 on Cognition, Memory, and the Microbiome in Mouse Models

Abstract

ONC-201 is the founding member of a class of compounds named impiridones and is currently in Phase III clinical trials. ONC-201 appears to possess strong anti-cancer abilities even in gliomas with H3K27M mutations that are typically more resilient to treatment. Unfortunately, there has been limited research studying the short-term and long-term effects of ONC-201 and the impact of succinylation on H3K27M. This research aims to provide an understanding of the consequences of ONC-201 on cognition, memory, and the microbiome in a mouse model and what influence succinylation of H3K27M may have in tumor proliferation.

Primary Faculty Mentor Name

James Stafford

Graduate Student Mentors

Alqassem Abuarqoub, Theresa Montgomery

Faculty/Staff Collaborators

Dr. Dimitry Krementsov

Status

Undergraduate

Student College

College of Arts and Sciences

Second Student College

College of Agriculture and Life Sciences

Program/Major

Biochemistry

Second Program/Major

Biological Science

Primary Research Category

Biological Sciences

Secondary Research Category

Health Sciences

Abstract only.

Share

COinS
 

The Impact of ONC-201 on Cognition, Memory, and the Microbiome in Mouse Models

ONC-201 is the founding member of a class of compounds named impiridones and is currently in Phase III clinical trials. ONC-201 appears to possess strong anti-cancer abilities even in gliomas with H3K27M mutations that are typically more resilient to treatment. Unfortunately, there has been limited research studying the short-term and long-term effects of ONC-201 and the impact of succinylation on H3K27M. This research aims to provide an understanding of the consequences of ONC-201 on cognition, memory, and the microbiome in a mouse model and what influence succinylation of H3K27M may have in tumor proliferation.