Thyroid Hormone Receptor Beta Decreases Expression of the Oncogene CEMIP in Thyroid Cancer
Conference Year
January 2022
Abstract
Anaplastic thyroid cancer (ATC) is one of the most lethal cancers, yet there are few therapeutic treatments that increase patient survival. Our research focuses on two proteins: cell migration-inducing protein (CEMIP), an oncogene known for promoting migration and invasion, and thyroid hormone receptor beta (TRβ), a tumor suppressor. We are investigating how TRβ expression and activation impact the expression of CEMIP in ATC cells. We have found that CEMIP is highly expressed in ATC cells, and that TRβ decreases CEMIP expression. This suggests that TRβ presence and activation may be a tumor suppressor in part by regulating CEMIP expression.
Primary Faculty Mentor Name
Frances Carr
Secondary Mentor Name
Jenny Tomczak
Graduate Student Mentors
Cole Davidson
Status
Undergraduate
Student College
College of Arts and Sciences
Program/Major
Biochemistry
Primary Research Category
Biological Sciences
Thyroid Hormone Receptor Beta Decreases Expression of the Oncogene CEMIP in Thyroid Cancer
Anaplastic thyroid cancer (ATC) is one of the most lethal cancers, yet there are few therapeutic treatments that increase patient survival. Our research focuses on two proteins: cell migration-inducing protein (CEMIP), an oncogene known for promoting migration and invasion, and thyroid hormone receptor beta (TRβ), a tumor suppressor. We are investigating how TRβ expression and activation impact the expression of CEMIP in ATC cells. We have found that CEMIP is highly expressed in ATC cells, and that TRβ decreases CEMIP expression. This suggests that TRβ presence and activation may be a tumor suppressor in part by regulating CEMIP expression.