Effect of Cystic Fibrosis treatment drugs on lung-specific cell toxicity
Conference Year
January 2022
Abstract
The work I started during my fellowship addressed whether two Cystic Fibrosis (CF) treatments, Tezacaftor and Ivacaftor, lead to toxicity in human lung-specific cell types, such as bronchial epithelial (HBE) cells. Some of the work had been already completed. My particular task was to work with HBE cells. I learned tissue culturing techniques and experimental design and then did a trial run, without drug treatment, to master the assay techniques. Although I will finalize the work this summer, my fellowship experience has been invaluable and will help me complete a critical experiment by assessing the toxicity of these CF drugs.
Primary Faculty Mentor Name
Dr. Daniel Weiss
Secondary Mentor Name
Loredana Asarian
Graduate Student Mentors
Evan Hoffman, Jayita Barua
Status
Undergraduate
Student College
College of Engineering and Mathematical Sciences
Program/Major
Biomedical Engineering
Primary Research Category
Biological Sciences
Effect of Cystic Fibrosis treatment drugs on lung-specific cell toxicity
The work I started during my fellowship addressed whether two Cystic Fibrosis (CF) treatments, Tezacaftor and Ivacaftor, lead to toxicity in human lung-specific cell types, such as bronchial epithelial (HBE) cells. Some of the work had been already completed. My particular task was to work with HBE cells. I learned tissue culturing techniques and experimental design and then did a trial run, without drug treatment, to master the assay techniques. Although I will finalize the work this summer, my fellowship experience has been invaluable and will help me complete a critical experiment by assessing the toxicity of these CF drugs.