Effect of Cystic Fibrosis treatment drugs on lung-specific cell toxicity

Abstract

The work I started during my fellowship addressed whether two Cystic Fibrosis (CF) treatments, Tezacaftor and Ivacaftor, lead to toxicity in human lung-specific cell types, such as bronchial epithelial (HBE) cells. Some of the work had been already completed. My particular task was to work with HBE cells. I learned tissue culturing techniques and experimental design and then did a trial run, without drug treatment, to master the assay techniques. Although I will finalize the work this summer, my fellowship experience has been invaluable and will help me complete a critical experiment by assessing the toxicity of these CF drugs.

Primary Faculty Mentor Name

Dr. Daniel Weiss

Secondary Mentor Name

Loredana Asarian

Graduate Student Mentors

Evan Hoffman, Jayita Barua

Status

Undergraduate

Student College

College of Engineering and Mathematical Sciences

Program/Major

Biomedical Engineering

Primary Research Category

Biological Sciences

Abstract only.

Share

COinS
 

Effect of Cystic Fibrosis treatment drugs on lung-specific cell toxicity

The work I started during my fellowship addressed whether two Cystic Fibrosis (CF) treatments, Tezacaftor and Ivacaftor, lead to toxicity in human lung-specific cell types, such as bronchial epithelial (HBE) cells. Some of the work had been already completed. My particular task was to work with HBE cells. I learned tissue culturing techniques and experimental design and then did a trial run, without drug treatment, to master the assay techniques. Although I will finalize the work this summer, my fellowship experience has been invaluable and will help me complete a critical experiment by assessing the toxicity of these CF drugs.