Endoplasmic reticulum moves by hitchhiking on multiple Rab vesicles
Conference Year
2023
Abstract
Endoplasmic Reticulum (ER) movement is critical to many cellular processes, and defects in ER movement have been linked to many diseases. There are two canonical mechanisms of ER movement (sliding and tip attachment complexes), but a novel mechanism has emerged where ER tubules “hitchhike” on motile Rab-vesicles. We found that Rab-vesicle movement is required for complete ER movement, indicating that hitchhiking may be a major mode of ER transport and providing a new direction of research for connections between ER dynamics and disease
Primary Faculty Mentor Name
John Salogiannis
Status
Graduate
Student College
Larner College of Medicine
Program/Major
Cellular, Molecular and Biomedical Sciences
Primary Research Category
Life Sciences
Endoplasmic reticulum moves by hitchhiking on multiple Rab vesicles
Endoplasmic Reticulum (ER) movement is critical to many cellular processes, and defects in ER movement have been linked to many diseases. There are two canonical mechanisms of ER movement (sliding and tip attachment complexes), but a novel mechanism has emerged where ER tubules “hitchhike” on motile Rab-vesicles. We found that Rab-vesicle movement is required for complete ER movement, indicating that hitchhiking may be a major mode of ER transport and providing a new direction of research for connections between ER dynamics and disease