The roles of Grb2 adaptor proteins in zebrafish development
Conference Year
2023
Abstract
Grb2 is an adaptor protein involved in Ras signaling and important for cell division, adhesion, migration, and angiogenesis. Adaptor proteins are critical for development by tethering molecules to initiate and/or propagate these cellular responses. Most studies address Grb2’s role in the vasculature system or in cell culture, therefore little is known about Grb2’s role in the nervous system. In situ hybridization demonstrates ubiquitous nervous tissue expression of grb2a and grb2b in zebrafish. Loss of Grb2 leads to abnormalities in brain size, retinal patterning, and the peripheral nervous system, highlighting the role for Grb2 in nervous tissue development in zebrafish.
Primary Faculty Mentor Name
Alicia Ebert
Graduate Student Mentors
Helaina Stergas
Status
Undergraduate
Student College
College of Arts and Sciences
Program/Major
Biological Science
Primary Research Category
Life Sciences
The roles of Grb2 adaptor proteins in zebrafish development
Grb2 is an adaptor protein involved in Ras signaling and important for cell division, adhesion, migration, and angiogenesis. Adaptor proteins are critical for development by tethering molecules to initiate and/or propagate these cellular responses. Most studies address Grb2’s role in the vasculature system or in cell culture, therefore little is known about Grb2’s role in the nervous system. In situ hybridization demonstrates ubiquitous nervous tissue expression of grb2a and grb2b in zebrafish. Loss of Grb2 leads to abnormalities in brain size, retinal patterning, and the peripheral nervous system, highlighting the role for Grb2 in nervous tissue development in zebrafish.