Characterization of the Receptors that Mediate the Prokinetic Effects of 5-HT4 Agonists on Propulsive Motility
Conference Year
2023
Abstract
Functional gastrointestinal disorders are very common, with a frequent symptom of these conditions being constipation. One of the most effective treatments for constipation involves 5- HT4 receptor agonists, but it is not clear whether they act on receptors in the mucosa or muscularis. Transgenic mouse strains in which this receptor is tissue-specifically down-regulated were utilized and motility assays were performed with test compounds that activate the 5-HT4 receptor. The agonists were found to have inconsistent results on the different mouse strains, which may be a result of ineffective knockdown of the receptors.
Primary Faculty Mentor Name
Gary Mawe
Status
Undergraduate
Student College
College of Agriculture and Life Sciences
Second Student College
Patrick Leahy Honors College
Program/Major
Biological Science
Primary Research Category
Life Sciences
Characterization of the Receptors that Mediate the Prokinetic Effects of 5-HT4 Agonists on Propulsive Motility
Functional gastrointestinal disorders are very common, with a frequent symptom of these conditions being constipation. One of the most effective treatments for constipation involves 5- HT4 receptor agonists, but it is not clear whether they act on receptors in the mucosa or muscularis. Transgenic mouse strains in which this receptor is tissue-specifically down-regulated were utilized and motility assays were performed with test compounds that activate the 5-HT4 receptor. The agonists were found to have inconsistent results on the different mouse strains, which may be a result of ineffective knockdown of the receptors.