Spatial and Working Memory in Mice post Traumatic Brain Injury
Conference Year
2023
Abstract
This study seeks to illuminate the effects of traumatic brain injuries (TBI) on the spatial and working memory of mice. It is hypothesized that three sequential low-level blast waves will impair the spatial memory capabilities of mice compared to uninjured mice. Mice first train on a spatial accuracy task based on automated food rewards, are then given three mild TBI, followed by testing on the accuracy task again. The mice with a TBI had interference of their working memory and had trouble differentiating between the correct goal areas compared to controls. This data can be used to determine cognitive differences in individuals with a blast injury.
Primary Faculty Mentor Name
Kalev Freeman
Secondary Mentor Name
Jeremy Barry
Status
Undergraduate
Student College
College of Arts and Sciences
Second Student College
Patrick Leahy Honors College
Program/Major
Biology
Primary Research Category
Life Sciences
Spatial and Working Memory in Mice post Traumatic Brain Injury
This study seeks to illuminate the effects of traumatic brain injuries (TBI) on the spatial and working memory of mice. It is hypothesized that three sequential low-level blast waves will impair the spatial memory capabilities of mice compared to uninjured mice. Mice first train on a spatial accuracy task based on automated food rewards, are then given three mild TBI, followed by testing on the accuracy task again. The mice with a TBI had interference of their working memory and had trouble differentiating between the correct goal areas compared to controls. This data can be used to determine cognitive differences in individuals with a blast injury.