Size-Specific Nanoparticles as Treatment for Vascular Disease
Conference Year
2024
Abstract
In Ischemic Strokes, blood clots block blood flow to surrounding tissue leading to necrosis of cells and potentially death. One promising method of treating this condition is using vasodilators. Vasodilation occurs as the result of an influx of calcium in endothelial cells that triggers hyperpolarization of the endothelial and smooth muscle membranes. Recent work within our lab demonstrates that inorganic nanoparticles within a small size range can induce calcium uptake in the endothelium via the action of the transient receptor potential vanilloid-type 4 (TRPV4) cation channel. We hypothesize that 20 nm gold nanoparticles will trigger a vasodilation pathway through TRPV4.
Primary Faculty Mentor Name
Amber Doiron
Status
Graduate
Student College
College of Engineering and Mathematical Sciences
Program/Major
Biomedical Engineering
Primary Research Category
Engineering and Math Science
Size-Specific Nanoparticles as Treatment for Vascular Disease
In Ischemic Strokes, blood clots block blood flow to surrounding tissue leading to necrosis of cells and potentially death. One promising method of treating this condition is using vasodilators. Vasodilation occurs as the result of an influx of calcium in endothelial cells that triggers hyperpolarization of the endothelial and smooth muscle membranes. Recent work within our lab demonstrates that inorganic nanoparticles within a small size range can induce calcium uptake in the endothelium via the action of the transient receptor potential vanilloid-type 4 (TRPV4) cation channel. We hypothesize that 20 nm gold nanoparticles will trigger a vasodilation pathway through TRPV4.