The Investigation of the Antioxidant Properties of SS-31 Analogs in Relation to Lipid Peroxidation
Conference Year
2024
Abstract
Mitochondria are found in all human cells, and they are responsible for creating the majority of ATP. The membranes of the mitochondria are easily oxidized, and this can lead to many diseases and adverse effects. This project seeks to develop an improved version of a mitochondrial targeting peptide called SS-31. The improvement will be achieved by replacing the antioxidant amino acid with an amino acid called 2-thiohistidine (2TH).The hypothesis is that peptide analogues of SS-31 containing multiple 2TH residues will prevent lipid oxidation at lower concentrations than those containing only one 2TH residue or only other antioxidant residues.
Primary Faculty Mentor Name
Robert Hondal
Status
Undergraduate
Student College
College of Arts and Sciences
Second Student College
Patrick Leahy Honors College
Program/Major
Chemistry
Second Program/Major
Classics/Classical Civilization
Primary Research Category
Physical Science
The Investigation of the Antioxidant Properties of SS-31 Analogs in Relation to Lipid Peroxidation
Mitochondria are found in all human cells, and they are responsible for creating the majority of ATP. The membranes of the mitochondria are easily oxidized, and this can lead to many diseases and adverse effects. This project seeks to develop an improved version of a mitochondrial targeting peptide called SS-31. The improvement will be achieved by replacing the antioxidant amino acid with an amino acid called 2-thiohistidine (2TH).The hypothesis is that peptide analogues of SS-31 containing multiple 2TH residues will prevent lipid oxidation at lower concentrations than those containing only one 2TH residue or only other antioxidant residues.