Quantification of Functional Tissue Factor Activity on Microvesicles During the Peripartum Period
Conference Year
2024
Abstract
During pregnancy, the risk of thrombotic events, such as deep vein thrombosis and pulmonary embolism, increases due to various physiological changes in the body. Microvesicles (MVs), which are small membranous vesicles shed from various cell types, including platelets, endothelial cells, and leukocytes, have been shown to increase during pregnancy and other disease states. Recently, it has been hypothesized that microvesicles bearing procoagulant molecules may contribute to this increased thrombotic risk during the peripartum period. Tissue factor, a transmembrane cofactor expressed on endothelial cells, serves as a potential target for these analyses due to its potential for initiating blood coagulation.
Primary Faculty Mentor Name
Maria Cristina Bravo
Status
Undergraduate
Student College
College of Agriculture and Life Sciences
Program/Major
Microbiology
Primary Research Category
Life Sciences
Quantification of Functional Tissue Factor Activity on Microvesicles During the Peripartum Period
During pregnancy, the risk of thrombotic events, such as deep vein thrombosis and pulmonary embolism, increases due to various physiological changes in the body. Microvesicles (MVs), which are small membranous vesicles shed from various cell types, including platelets, endothelial cells, and leukocytes, have been shown to increase during pregnancy and other disease states. Recently, it has been hypothesized that microvesicles bearing procoagulant molecules may contribute to this increased thrombotic risk during the peripartum period. Tissue factor, a transmembrane cofactor expressed on endothelial cells, serves as a potential target for these analyses due to its potential for initiating blood coagulation.