Taste cells expressing Ionotropic Receptor 94e reciprocally impact feeding and egg laying in Drosophila
Conference Year
2024
Abstract
Chemosensory cells across the body of Drosophila melanogaster evaluate the environment and play a crucial role in neural circuits that prioritize feeding, mating, or egg laying. Previous mapping of gustatory receptor neurons (GRNs) on the fly labellum identified a set of neurons defined by expression of Ionotropic Receptor 94e (IR94e), but the impact of IR94e GRNs on behavior remained unclear. We used optogenetics and chemogenetics, in vivo calcium imaging, and feeding and oviposition assays to elucidate that IR94e is necessary for the detection of some amino acids and reciprocally drives egg laying and prevents feeding behaviors.
Primary Faculty Mentor Name
Molly Stanley
Status
Graduate
Student College
College of Arts and Sciences
Program/Major
Biology
Primary Research Category
Life Sciences
Taste cells expressing Ionotropic Receptor 94e reciprocally impact feeding and egg laying in Drosophila
Chemosensory cells across the body of Drosophila melanogaster evaluate the environment and play a crucial role in neural circuits that prioritize feeding, mating, or egg laying. Previous mapping of gustatory receptor neurons (GRNs) on the fly labellum identified a set of neurons defined by expression of Ionotropic Receptor 94e (IR94e), but the impact of IR94e GRNs on behavior remained unclear. We used optogenetics and chemogenetics, in vivo calcium imaging, and feeding and oviposition assays to elucidate that IR94e is necessary for the detection of some amino acids and reciprocally drives egg laying and prevents feeding behaviors.