Genetic predisposition to breast cancer
Abstract
Genetic predisposition is a critical determinant of breast and ovarian cancer susceptibility, with pathogenic variants in BRCA1 and BRCA2 conferring significantly elevated risk. This infographic delineates key genetic risk factors, screening protocols, and preventive interventions, emphasizing the role of genetic counseling in risk assessment and clinical decision-making. Advanced methodologies, including HRDetect and polygenic risk scores, facilitate precise risk stratification and therapeutic targeting. Prophylactic interventions and pharmacological strategies, such as PARP inhibitors, exploit molecular vulnerabilities in DNA repair pathways. A comprehensive understanding of hereditary risk enables precision medicine approaches, optimizing early detection and personalized cancer prevention strategies.
Primary Faculty Mentor Name
Melissa Pespeni
Status
Undergraduate
Student College
College of Agriculture and Life Sciences
Program/Major
Biology
Primary Research Category
Life Sciences
Genetic predisposition to breast cancer
Genetic predisposition is a critical determinant of breast and ovarian cancer susceptibility, with pathogenic variants in BRCA1 and BRCA2 conferring significantly elevated risk. This infographic delineates key genetic risk factors, screening protocols, and preventive interventions, emphasizing the role of genetic counseling in risk assessment and clinical decision-making. Advanced methodologies, including HRDetect and polygenic risk scores, facilitate precise risk stratification and therapeutic targeting. Prophylactic interventions and pharmacological strategies, such as PARP inhibitors, exploit molecular vulnerabilities in DNA repair pathways. A comprehensive understanding of hereditary risk enables precision medicine approaches, optimizing early detection and personalized cancer prevention strategies.
