Designing and synthesizing raman imaging probes to monitor chemical interactions and dynamics of polymer-based gene delivery vehicles in biological cells

Presenter's Name(s)

Cole Wright

Abstract

Raman spectroscopy excites molecular vibrations, which can be used to monitor the structural dynamics of chemical bonds in molecules. However, many biomolecules are difficult to visualize with Raman alone due to weak signals and cellular background noise. My research focuses on developing Raman probes that are both intense and chemically sensitive, enabling real-time tracking of biomolecules in live cells, and monitoring of chemical dynamics. These tags will be attached to synthetic gene delivery polymers to better understand the chemical interactions that contribute to effective gene delivery.

Primary Faculty Mentor Name

David Punihaole

Status

Undergraduate

Student College

College of Arts and Sciences

Program/Major

Biochemistry

Primary Research Category

Life Sciences

Abstract only.

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Designing and synthesizing raman imaging probes to monitor chemical interactions and dynamics of polymer-based gene delivery vehicles in biological cells

Raman spectroscopy excites molecular vibrations, which can be used to monitor the structural dynamics of chemical bonds in molecules. However, many biomolecules are difficult to visualize with Raman alone due to weak signals and cellular background noise. My research focuses on developing Raman probes that are both intense and chemically sensitive, enabling real-time tracking of biomolecules in live cells, and monitoring of chemical dynamics. These tags will be attached to synthetic gene delivery polymers to better understand the chemical interactions that contribute to effective gene delivery.