Investigating sex differences in PAC1 receptor density within the retrospinal cortex: Implications for post-traumatic stress disorder
Abstract
This project focused on the sex differences present in Post Traumatic Stress Disorder (PTSD), where females are more susceptible. The study noted dysregulation of neural circuitry of the pituitary adenylate cyclase-activating peptide (PACAP) involved in stress disorders. Overall, there is limited research regarding the density of PACAP receptors in certain parts of the brain, such as the retrosplenial cortex (RSC). This experiment analyzed the RSC, context specific region of the brain, in mice through PAC1 receptor expression density recorded from an mCherry virus injection. The differences were noted and potential implications that contribute to PTSD and its overall course.
Primary Faculty Mentor Name
Jom Hammack
Status
Undergraduate
Student College
College of Arts and Sciences
Program/Major
Psychological Science
Primary Research Category
Physical Science
Investigating sex differences in PAC1 receptor density within the retrospinal cortex: Implications for post-traumatic stress disorder
This project focused on the sex differences present in Post Traumatic Stress Disorder (PTSD), where females are more susceptible. The study noted dysregulation of neural circuitry of the pituitary adenylate cyclase-activating peptide (PACAP) involved in stress disorders. Overall, there is limited research regarding the density of PACAP receptors in certain parts of the brain, such as the retrosplenial cortex (RSC). This experiment analyzed the RSC, context specific region of the brain, in mice through PAC1 receptor expression density recorded from an mCherry virus injection. The differences were noted and potential implications that contribute to PTSD and its overall course.
