Impact of Vitamin D Supplementation in the Mouse Model of Obesity and Insulin Resistance
Conference Year
January 2022
Abstract
VitaminD deficiency has risen as a potential environmental factor that increases propensity to type 1 diabetes (T1D) and type 2 diabetes (T2D). To study implications in clinical management of T1D/T2D via VitaminD supplementation, a mouse model was developed with half receiving a high fat diet and the other half receiving chow. Each diet was supplemented with 1000IU or 5000IU of VitaminD. Increased insulin circulating levels were associated with higher VitaminD supplementation even in a metabolically stressful environment. Changes in insulin secretion associated with VitaminD supplementation show the potential of VitaminD as a tool for clinical management of T1D/T2D.
Primary Faculty Mentor Name
Dhananjay Gupta
Faculty/Staff Collaborators
Thoma L. Jetton, Keara McElroy-Yaggy
Status
Undergraduate
Student College
College of Agriculture and Life Sciences
Program/Major
Microbiology
Primary Research Category
Biological Sciences
Secondary Research Category
Health Sciences
Impact of Vitamin D Supplementation in the Mouse Model of Obesity and Insulin Resistance
VitaminD deficiency has risen as a potential environmental factor that increases propensity to type 1 diabetes (T1D) and type 2 diabetes (T2D). To study implications in clinical management of T1D/T2D via VitaminD supplementation, a mouse model was developed with half receiving a high fat diet and the other half receiving chow. Each diet was supplemented with 1000IU or 5000IU of VitaminD. Increased insulin circulating levels were associated with higher VitaminD supplementation even in a metabolically stressful environment. Changes in insulin secretion associated with VitaminD supplementation show the potential of VitaminD as a tool for clinical management of T1D/T2D.