Impact of Vitamin D Supplementation in the Mouse Model of Obesity and Insulin Resistance

Presenter's Name(s)

Patricio Flores-BringasFollow

Abstract

VitaminD deficiency has risen as a potential environmental factor that increases propensity to type 1 diabetes (T1D) and type 2 diabetes (T2D). To study implications in clinical management of T1D/T2D via VitaminD supplementation, a mouse model was developed with half receiving a high fat diet and the other half receiving chow. Each diet was supplemented with 1000IU or 5000IU of VitaminD. Increased insulin circulating levels were associated with higher VitaminD supplementation even in a metabolically stressful environment. Changes in insulin secretion associated with VitaminD supplementation show the potential of VitaminD as a tool for clinical management of T1D/T2D.

Primary Faculty Mentor Name

Dhananjay Gupta

Faculty/Staff Collaborators

Thoma L. Jetton, Keara McElroy-Yaggy

Status

Undergraduate

Student College

College of Agriculture and Life Sciences

Program/Major

Microbiology

Primary Research Category

Biological Sciences

Secondary Research Category

Health Sciences

Abstract only.

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Impact of Vitamin D Supplementation in the Mouse Model of Obesity and Insulin Resistance

VitaminD deficiency has risen as a potential environmental factor that increases propensity to type 1 diabetes (T1D) and type 2 diabetes (T2D). To study implications in clinical management of T1D/T2D via VitaminD supplementation, a mouse model was developed with half receiving a high fat diet and the other half receiving chow. Each diet was supplemented with 1000IU or 5000IU of VitaminD. Increased insulin circulating levels were associated with higher VitaminD supplementation even in a metabolically stressful environment. Changes in insulin secretion associated with VitaminD supplementation show the potential of VitaminD as a tool for clinical management of T1D/T2D.