Investigating immune-stroma signaling landscape in the developing meninges
Conference Year
January 2022
Abstract
Recent research has revealed that populations of immune cells outside of the brain parenchyma influence the brain itself. These immune cells are located in border tissues such as the meninges. The meninges host a rich and dynamic immune environment, housing innate myeloid cells and T cells. This protective tissue is also home to diverse groups of stromal cells which likely provide a niche that supports immune function in the meninges. Here, we investigate the cross-talk between immune and stromal cell populations through development and into aging in the mouse, and how known signaling pathways are altered throughout aging.
Primary Faculty Mentor Name
Julie.Dragon@uvm.edu
Secondary Mentor Name
Beth Stevens
Graduate Student Mentors
Alec Walker
Faculty/Staff Collaborators
Vahid Gazestani
Student Collaborators
Theodore Fisher
Status
Undergraduate
Student College
College of Agriculture and Life Sciences
Program/Major
Molecular Genetics
Second Program/Major
Microbiology
Primary Research Category
Biological Sciences
Investigating immune-stroma signaling landscape in the developing meninges
Recent research has revealed that populations of immune cells outside of the brain parenchyma influence the brain itself. These immune cells are located in border tissues such as the meninges. The meninges host a rich and dynamic immune environment, housing innate myeloid cells and T cells. This protective tissue is also home to diverse groups of stromal cells which likely provide a niche that supports immune function in the meninges. Here, we investigate the cross-talk between immune and stromal cell populations through development and into aging in the mouse, and how known signaling pathways are altered throughout aging.