Gold Nanoparticle Modification of Carbon Fiber Microelectrodes for in vivo Acetylcholine Detection Using Fast Scan Cyclic Voltammetry
Conference Year
2024
Abstract
Acetylcholine (ACh) is suspected to play a role in cognitive decline in Alzheimer’s Disease (AD). However, the available technology to measure ACh in situ is not adequate in detecting ACh in such a small spatial and short time scale. We aim to increase the sensitivity of the sensor by modifying carbon fiber microelectrodes with gold nanoparticles and verify sensitivity using fast scan cyclic voltammetry. We hypothesize that lower ACh levels will be associated with greater cognitive decline. By constructing a small, biocompatible sensor that can measure ACh in vivo in AD models, we aim to elucidate the neurotransmitter’s role AD.
Primary Faculty Mentor Name
Yangguang Ou
Status
Undergraduate
Student College
College of Arts and Sciences
Program/Major
Neuroscience
Primary Research Category
Life Sciences
Gold Nanoparticle Modification of Carbon Fiber Microelectrodes for in vivo Acetylcholine Detection Using Fast Scan Cyclic Voltammetry
Acetylcholine (ACh) is suspected to play a role in cognitive decline in Alzheimer’s Disease (AD). However, the available technology to measure ACh in situ is not adequate in detecting ACh in such a small spatial and short time scale. We aim to increase the sensitivity of the sensor by modifying carbon fiber microelectrodes with gold nanoparticles and verify sensitivity using fast scan cyclic voltammetry. We hypothesize that lower ACh levels will be associated with greater cognitive decline. By constructing a small, biocompatible sensor that can measure ACh in vivo in AD models, we aim to elucidate the neurotransmitter’s role AD.