Characterization of APOBEC3A Regulation through Protein–protein interactions
Conference Year
2024
Abstract
My project aims to characterize the protein-protein interactions of APOBEC3A (A3A). A3A is a cytidine deaminase involved in viral innate immune response, and whose dysregulation has previously been identified in approximately 50% of all cancer genomes. Specific interacting proteins that have been identified include HEXIM1 and TAX1BP1, which are both involved in innate immune response. Characterization of how identified proteins interact with A3A may explain how their interactions may contribute to A3A-induced mutagenesis. This increased understanding would provide a basis for future research with APOBEC3A including controlling A3A regulation and reducing A3A induced cancer mutagenesis.
Primary Faculty Mentor Name
Steven Roberts
Status
Undergraduate
Student College
College of Agriculture and Life Sciences
Second Student College
Patrick Leahy Honors College
Program/Major
Microbiology and Molecular Genetics
Primary Research Category
Life Sciences
Characterization of APOBEC3A Regulation through Protein–protein interactions
My project aims to characterize the protein-protein interactions of APOBEC3A (A3A). A3A is a cytidine deaminase involved in viral innate immune response, and whose dysregulation has previously been identified in approximately 50% of all cancer genomes. Specific interacting proteins that have been identified include HEXIM1 and TAX1BP1, which are both involved in innate immune response. Characterization of how identified proteins interact with A3A may explain how their interactions may contribute to A3A-induced mutagenesis. This increased understanding would provide a basis for future research with APOBEC3A including controlling A3A regulation and reducing A3A induced cancer mutagenesis.