Traumatic brain Injury Impact on Spatial and Working Memory in Mice
Conference Year
2024
Abstract
The objective of this research is to demonstrate how spatial and working memory is impacted by Traumatic Brain Injury (TBI). We hypothesized that a series of low-level blast waves would impair the spatial and working memory of our mice models compared to the control mice models who did not receive any injury. For our methods, 6 mice models of male C57BL/6 mice between 10-14 weeks underwent an 85% baseline food restriction and were trained on a spatial-accuracy task. The mice then received a series of low-level TBI blasts. The mice were tested on the spatial-accuracy task again post-TBI. The results for our preliminary data shows that the TBI mice experienced a decrease in working memory and no observed motor defects compared to the control mice. It was concluded from our preliminary data that hippocampal independent and dependent spatial memory remained intact after the series of low-level blasts.
Primary Faculty Mentor Name
Kalev Freeman
Status
Undergraduate
Student College
College of Arts and Sciences
Program/Major
Biological Sciences, Integrated
Primary Research Category
Clinical
Traumatic brain Injury Impact on Spatial and Working Memory in Mice
The objective of this research is to demonstrate how spatial and working memory is impacted by Traumatic Brain Injury (TBI). We hypothesized that a series of low-level blast waves would impair the spatial and working memory of our mice models compared to the control mice models who did not receive any injury. For our methods, 6 mice models of male C57BL/6 mice between 10-14 weeks underwent an 85% baseline food restriction and were trained on a spatial-accuracy task. The mice then received a series of low-level TBI blasts. The mice were tested on the spatial-accuracy task again post-TBI. The results for our preliminary data shows that the TBI mice experienced a decrease in working memory and no observed motor defects compared to the control mice. It was concluded from our preliminary data that hippocampal independent and dependent spatial memory remained intact after the series of low-level blasts.