Therapeutic Ketosis Attenuates Asthma Associated Airway Hyperresponsiveness by Targeting Bronchial Smooth Muscle
Conference Year
2024
Abstract
Asthma is a complex lung condition characterized by heightened sensitivity to triggers culminating in airway constriction and breathing difficulties. During allergic asthma exacerbations, histamine release directly induces bronchial smooth muscle contraction and airway narrowing. Induced endogenously during diverse nutritional states, the ketone body, β-hydroxybutyrate (BHB), decreases asthma-induced airway constriction in vivo. In vitro mechaistic studies reveal that BHB mitigates histamine-induced calcium mobilization in and contraction of bronchial smooth muscle cells. These results suggest that elevating systemic BHB concentrations via dietary interventions could alleviate symptoms across various asthma subtypes through modulating bronchial smooth muscle cell signaling and function.
Primary Faculty Mentor Name
Matthew Poynter
Status
Graduate
Student College
Larner College of Medicine
Program/Major
Cellular, Molecular and Biomedical Sciences
Primary Research Category
Life Sciences
Therapeutic Ketosis Attenuates Asthma Associated Airway Hyperresponsiveness by Targeting Bronchial Smooth Muscle
Asthma is a complex lung condition characterized by heightened sensitivity to triggers culminating in airway constriction and breathing difficulties. During allergic asthma exacerbations, histamine release directly induces bronchial smooth muscle contraction and airway narrowing. Induced endogenously during diverse nutritional states, the ketone body, β-hydroxybutyrate (BHB), decreases asthma-induced airway constriction in vivo. In vitro mechaistic studies reveal that BHB mitigates histamine-induced calcium mobilization in and contraction of bronchial smooth muscle cells. These results suggest that elevating systemic BHB concentrations via dietary interventions could alleviate symptoms across various asthma subtypes through modulating bronchial smooth muscle cell signaling and function.