Impact of Ionotropic Receptor Mutants on an Amino Acid Feeding Response
Conference Year
2024
Abstract
Drosophila melanogaster have similar food-sensing behaviors to humans. The complete mechanism for tasting amino acids is still unknown across organisms. We identified the role of different ionotropic receptors (IR) in amino acid feeding behavior by observing proboscis extension response (PER) in mutated flies. Three mutant ionotropic receptors were studied for their effect on PER. Homozygous mutations in IR76b and IR25a showed decreased PER, whereas IR94e showed an increased feeding response. Uniquely, we found an intermediate response occurs in heterozygous phenotypes. Our data suggests that IRs play an important role in amino acid detecting.
Primary Faculty Mentor Name
Molly Stanley
Graduate Student Mentors
Jacqueline Guillemin
Status
Undergraduate
Student College
College of Agriculture and Life Sciences
Program/Major
Biological Science
Primary Research Category
Life Sciences
Impact of Ionotropic Receptor Mutants on an Amino Acid Feeding Response
Drosophila melanogaster have similar food-sensing behaviors to humans. The complete mechanism for tasting amino acids is still unknown across organisms. We identified the role of different ionotropic receptors (IR) in amino acid feeding behavior by observing proboscis extension response (PER) in mutated flies. Three mutant ionotropic receptors were studied for their effect on PER. Homozygous mutations in IR76b and IR25a showed decreased PER, whereas IR94e showed an increased feeding response. Uniquely, we found an intermediate response occurs in heterozygous phenotypes. Our data suggests that IRs play an important role in amino acid detecting.