Investigation of the Sigmatropic Rearrangement of Allenyl Cyanamides
Conference Year
2024
Abstract
The sigmatropic rearrangement of allenyl cyanamides was studied for its hypothesized utility in effectively producing stable cyclic guanidine products. Investigating pathways to cyclic guanidines has considerable applications in the preparation of biologically active guanidine natural products. The proposed reaction has the unique characteristic of only proceeding above room temperature, unlike similar reactions previously explored. This allows for the purification of the starting material before any reactivity takes place, thereby increasing reaction efficiency. Developing new synthetic pathways to form cyclic guanidines has potential to contribute to the future preparations of guanidine natural products and their related medically important analogs.
Primary Faculty Mentor Name
Jose S. Madalengoitia
Status
Undergraduate
Student College
College of Arts and Sciences
Program/Major
Chemistry
Primary Research Category
Physical Science
Investigation of the Sigmatropic Rearrangement of Allenyl Cyanamides
The sigmatropic rearrangement of allenyl cyanamides was studied for its hypothesized utility in effectively producing stable cyclic guanidine products. Investigating pathways to cyclic guanidines has considerable applications in the preparation of biologically active guanidine natural products. The proposed reaction has the unique characteristic of only proceeding above room temperature, unlike similar reactions previously explored. This allows for the purification of the starting material before any reactivity takes place, thereby increasing reaction efficiency. Developing new synthetic pathways to form cyclic guanidines has potential to contribute to the future preparations of guanidine natural products and their related medically important analogs.