The Role of Abl- and PKC-Dependent Reverse Signaling in Zebrafish Retinal Development
Conference Year
2024
Abstract
We have previously identified Sema6A and PlxnA2 to be necessary for eye size, eye field cohesion, and retinal lamination. Upon Sema6A and PlxnA2 binding, bidirectional signaling events revolving around Sema6A and PlxnA2 are referred to as reverse and forward signaling, respectively. Using zebrafish and cultured cells as models, we have previously characterized important features of forward signaling through PlxnA2, however, reverse signaling via Sema6A remains largely uncharted. Here we explore the functional relevance of Abl-mediated reverse signaling on retinal integrity. Together these data provide insight Sema6a reverse signaling and its role in the development of the neural retina.
Primary Faculty Mentor Name
Alicia Ebert
Status
Graduate
Student College
College of Arts and Sciences
Second Student College
Larner College of Medicine
Program/Major
Neuroscience
Primary Research Category
Life Sciences
The Role of Abl- and PKC-Dependent Reverse Signaling in Zebrafish Retinal Development
We have previously identified Sema6A and PlxnA2 to be necessary for eye size, eye field cohesion, and retinal lamination. Upon Sema6A and PlxnA2 binding, bidirectional signaling events revolving around Sema6A and PlxnA2 are referred to as reverse and forward signaling, respectively. Using zebrafish and cultured cells as models, we have previously characterized important features of forward signaling through PlxnA2, however, reverse signaling via Sema6A remains largely uncharted. Here we explore the functional relevance of Abl-mediated reverse signaling on retinal integrity. Together these data provide insight Sema6a reverse signaling and its role in the development of the neural retina.