The role of pharmacogenetics in adverse drug reactions
Abstract
Pharmacogenetics examines how genetic variations influence drug response, focusing on pharmacokinetics (drug absorption, distribution, metabolism, and excretion) and pharmacodynamics (drug effects on the body). By analyzing genetic differences that alter drug interactions, pharmacogenetics helps predict individual variations in drug metabolism and response, potentially identifying adverse drug reactions (ADRs) linked to single nucleotide polymorphisms (SNPs). The PREPARE study demonstrated the clinical benefits of pharmacogenetic panel implementation, showing its potential to reduce ADR severity and occurrence. These findings highlight the future role of pharmacogenetics in personalized medicine, improving drug safety and efficacy.
Primary Faculty Mentor Name
Melissa Pespeni
Status
Undergraduate
Student College
College of Arts and Sciences
Program/Major
Biology
Primary Research Category
Life Sciences
The role of pharmacogenetics in adverse drug reactions
Pharmacogenetics examines how genetic variations influence drug response, focusing on pharmacokinetics (drug absorption, distribution, metabolism, and excretion) and pharmacodynamics (drug effects on the body). By analyzing genetic differences that alter drug interactions, pharmacogenetics helps predict individual variations in drug metabolism and response, potentially identifying adverse drug reactions (ADRs) linked to single nucleotide polymorphisms (SNPs). The PREPARE study demonstrated the clinical benefits of pharmacogenetic panel implementation, showing its potential to reduce ADR severity and occurrence. These findings highlight the future role of pharmacogenetics in personalized medicine, improving drug safety and efficacy.
