The role of genetic mutations in bacterial antibiotic resistance

Presenter's Name(s)

Madeline Churchill

Abstract

Antibiotic resistance in bacteria has become a global epidemic, largely due to the misuse and overuse of antibiotics. Many bacteria acquire this resistance through genetic mutations, including spontaneous mutations, hypermutators, and horizontal gene transfer via conjugation, transformation, and transduction. These mutations lead to resistance by inactivating the antibiotic, modifying the target molecule, or utilizing efflux pumps. With this, studies are now focused on detecting mutations through DNA sequencing and PCR, which can improve the accuracy of diagnoses, guide appropriate antibiotic prescriptions, and lead to more effective treatment plans.

Primary Faculty Mentor Name

Melissa Pespeni

Status

Undergraduate

Student College

College of Arts and Sciences

Program/Major

Biology

Primary Research Category

Life Sciences

Abstract only.

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The role of genetic mutations in bacterial antibiotic resistance

Antibiotic resistance in bacteria has become a global epidemic, largely due to the misuse and overuse of antibiotics. Many bacteria acquire this resistance through genetic mutations, including spontaneous mutations, hypermutators, and horizontal gene transfer via conjugation, transformation, and transduction. These mutations lead to resistance by inactivating the antibiotic, modifying the target molecule, or utilizing efflux pumps. With this, studies are now focused on detecting mutations through DNA sequencing and PCR, which can improve the accuracy of diagnoses, guide appropriate antibiotic prescriptions, and lead to more effective treatment plans.