The phenotypic presentation and optokinetic response of DCBLD1 in zebrafish
Abstract
The orphan receptor DCBLD1 (Discoidin, Cub, and LCCL domain-containing receptor 1) is found in the plasma membrane of multiple tissue types in vertebrates. DCBLD1 is upregulated in tissues following vascular repair and tumor migration, but its specific function in nervous system development has not yet been determined. This study will delve into the effects on zebrafish development when DCBLD1 is absent by analyzing the retina's cellular integrity and optokinetic function compared to wildtype fish. Through this, knowledge of the necessity of DCBLD1 will be furthered and its impacts will be compared to its sister gene DCBLD2.
Primary Faculty Mentor Name
Alicia Ebert
Status
Graduate
Student College
College of Arts and Sciences
Program/Major
Biology
Primary Research Category
Life Sciences
The phenotypic presentation and optokinetic response of DCBLD1 in zebrafish
The orphan receptor DCBLD1 (Discoidin, Cub, and LCCL domain-containing receptor 1) is found in the plasma membrane of multiple tissue types in vertebrates. DCBLD1 is upregulated in tissues following vascular repair and tumor migration, but its specific function in nervous system development has not yet been determined. This study will delve into the effects on zebrafish development when DCBLD1 is absent by analyzing the retina's cellular integrity and optokinetic function compared to wildtype fish. Through this, knowledge of the necessity of DCBLD1 will be furthered and its impacts will be compared to its sister gene DCBLD2.
