The role of coregulators in TRβ-mediated tumor suppression in anaplastic thyroid cancer

Presenter's Name(s)

Sadie LaMothe

Abstract

Anaplastic thyroid cancer (ATC) is an aggressive form of dedifferentiated thyroid cancer responsible for approximately 40% of thyroid cancer-related deaths. Thyroid hormone receptor beta (TRβ), a nuclear hormone receptor, serves as a tumor suppressor in thyroid cancers and is downregulated in ATC. Lysine-specific demethylase 1 (LSD1), a potential TRβ binding partner, is upregulated in ATC and acts as a tumor promoter. These findings enable the visualization of TRβ and LSD1 colocalization in thyroid cell lines through immunofluorescence and suggest how manipulating their interactions could offer new therapeutic options for ATC patients.

Primary Faculty Mentor Name

Ellen Martinsen

Status

Undergraduate

Student College

College of Arts and Sciences

Program/Major

Cellular, Molecular and Biomedical Sciences

Primary Research Category

Life Sciences

Abstract only.

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The role of coregulators in TRβ-mediated tumor suppression in anaplastic thyroid cancer

Anaplastic thyroid cancer (ATC) is an aggressive form of dedifferentiated thyroid cancer responsible for approximately 40% of thyroid cancer-related deaths. Thyroid hormone receptor beta (TRβ), a nuclear hormone receptor, serves as a tumor suppressor in thyroid cancers and is downregulated in ATC. Lysine-specific demethylase 1 (LSD1), a potential TRβ binding partner, is upregulated in ATC and acts as a tumor promoter. These findings enable the visualization of TRβ and LSD1 colocalization in thyroid cell lines through immunofluorescence and suggest how manipulating their interactions could offer new therapeutic options for ATC patients.