The impact of Western diet and binge alcohol consumption on kidney oxidative stress
Abstract
Diet and alcohol consumption play a significant role in oxidative stress levels, which can negatively impact kidney function. This study evaluates the effects of a Western diet and binge ethanol consumption on kidney health. C57BL/6J mice (n=6-7 mice/sex/group) were assigned to control, control/binge, Western diet, or Western/Binge groups for 12 weeks. Analysis of malondialdehyde (MDA) levels, a marker of oxidative stress, showed Western diet increased MDA regardless of alcohol. Serum blood urea nitrogen and creatinine levels did not show significant differences. These findings suggest that diet and alcohol intake increase kidney oxidative damage.
Primary Faculty Mentor Name
Leo Tang
Status
Undergraduate
Student College
College of Arts and Sciences
Program/Major
Biology
Primary Research Category
Life Sciences
The impact of Western diet and binge alcohol consumption on kidney oxidative stress
Diet and alcohol consumption play a significant role in oxidative stress levels, which can negatively impact kidney function. This study evaluates the effects of a Western diet and binge ethanol consumption on kidney health. C57BL/6J mice (n=6-7 mice/sex/group) were assigned to control, control/binge, Western diet, or Western/Binge groups for 12 weeks. Analysis of malondialdehyde (MDA) levels, a marker of oxidative stress, showed Western diet increased MDA regardless of alcohol. Serum blood urea nitrogen and creatinine levels did not show significant differences. These findings suggest that diet and alcohol intake increase kidney oxidative damage.
